Figure: Activation of the AIM2 inflammasome in response to DNA damage (Mouse)¶
This pathway diagram illustrates the AIM2 inflammasome activation in response to DNA damage in mouse cells. The numbered steps show:
- DNA damage occurs at a double-strand break site within the nucleus
- AIM2 binds to DNA at the damage site and acts as a pattern recognition receptor (PRR)
- AIM2 exhibits signaling adaptor activity, leading to inflammasome assembly
- Caspase-1 is activated by the AIM2 inflammasome
- Active Caspase-1 cleaves Gasdermin D (GSDMD), which binds to PI(4,5)P₂ in the plasma membrane, forming pores that lead to pyroptosis and inflammatory response
The diagram faithfully represents all gene products and relationships from the GO-CAM model (MGI:MGI:96544 for Caspase-1, MGI:MGI:2686159 for AIM2, and MGI:MGI:1916396 for GSDMD) and their key molecular functions and biological processes.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the AIM2 inflammasome activation pathway in response to DNA damage. Each step is clearly numbered and visually distinct, making the progression easy to follow. The representation includes all key components from the GO-CAM model, showing how DNA damage triggers AIM2 binding, inflammasome assembly, Caspase-1 activation, and ultimately Gasdermin D-mediated pore formation leading to pyroptosis and inflammatory response.\n\nThe visual hierarchy is well established with appropriate use of shapes, colors, and typography. The legend explains each visual element, making the diagram accessible to readers. The layout is clean and follows the conventional top-to-bottom, left-to-right reading pattern, enhancing comprehension of the biological pathway.\n\nThe diagram successfully balances scientific accuracy with visual clarity, making it suitable for publication in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}