Figure: Activation of the AIM2 inflammasome in neural cells shapes neurodevelopment (Mouse)¶
AIM2: Absent in melanoma 2, a pattern recognition receptor that detects cytosolic double-stranded DNA ASC (PYCARD): Apoptosis-associated speck-like protein containing a CARD, acts as a signaling adaptor Caspase-1: A cysteine protease that cleaves pro-inflammatory cytokines and Gasdermin D GSDMD: Gasdermin D, forms pores in the plasma membrane when cleaved, leading to pyroptosis DNA damage: Site of double-strand break that activates AIM2 Membrane pore: Formed by cleaved GSDMD, allowing release of inflammatory mediators
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the AIM2 inflammasome pathway in neural cells. I've made several improvements to enhance clarity and scientific accuracy:\n\n1. Used distinct geometric shapes for different protein types to improve visual differentiation\n2. Added numbered steps to clarify the sequence of events\n3. Separated text elements to reduce overcrowding\n4. Enhanced the legend with more comprehensive protein descriptions\n5. Improved spacing and positioning of pathway components\n\nThe diagram accurately represents the GO-CAM model showing how DNA damage activates AIM2, which recruits ASC (PYCARD), leading to Caspase-1 activation, GSDMD cleavage, and ultimately pore formation and inflammatory response. The style is consistent with high-quality journal figures while maintaining scientific accuracy.","necessary_changes":"None needed. The diagram now has clear text placement with no overlapping elements, and uses appropriate shapes and colors to distinguish different components of the pathway.","optional_changes":"The diagram could be further enhanced with additional visual elements representing the inflammatory cytokines released during pyroptosis, but this would be supplementary to the core pathway already depicted."}