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Figure: MYD88-dependent TLR4 signaling pathway leading to autophagy activation (Human)

id: gomodel:6413ac9800000256

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This diagram illustrates the MYD88-dependent TLR4 signaling pathway leading to autophagy activation in human cells.

The pathway begins at the plasma membrane, where lipopolysaccharide (LPS) activates the TLR4 receptor (O00206), initiating a signaling cascade. TLR4 engages the adaptor proteins TIRAP (P58753) and MYD88 (Q99836) at the plasma membrane.

In the cytoplasm, MYD88 recruits and activates IRAK4 (Q9NWZ3), which then activates IRAK2 (O43187) through its protein kinase activity. IRAK2 subsequently activates TRAF6 (Q9Y4K3), which functions as a ubiquitin ligase. TRAF6 signals to BECN1 (Q14457), which ultimately leads to the activation of PIK3C3 (Q8NEB9), a phosphatidylinositol kinase. PIK3C3 activity is essential for autophagosome assembly (GO:0000045), the final outcome of this signaling pathway.

This pathway represents the molecular mechanisms connecting toll-like receptor signaling to the cellular autophagy process, a critical response for cellular homeostasis and defense against pathogens.

Feedback from AI on figure:

{"feedback":"The diagram effectively outlines the MYD88-dependent TLR4 signaling pathway with clear labeling of each component and its activity. The flow from the TLR4 receptor at the plasma membrane to autophagosome assembly is logically depicted with directional arrows, illustrating the signaling cascade. The use of different colors for each protein aids in differentiation and understanding.","necessary_changes":null,"optional_changes":null}