Figure: Thiamine diphosphate biosynthetic process 1 (Mouse)¶
This diagram illustrates the thiamine diphosphate biosynthetic process in mouse cells (GO:0009229). Thiamine is transported into the cell via two plasma membrane transporters: Slc19a2 (MGI:1928761) and Slc19a3 (MGI:1931307), both with thiamine transmembrane transporter activity (GO:0015234). Once in the cytosol, thiamine is phosphorylated by the enzyme Tpk1 (MGI:1352500) with thiamine diphosphokinase activity (GO:0004788) to form thiamine diphosphate (thiamine-PP). The thiamine diphosphate is then transported into mitochondria via the Slc25a19 transporter (MGI:1914533) with thiamine pyrophosphate transmembrane transporter activity (GO:0090422) located in the mitochondrial inner membrane.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the thiamine diphosphate biosynthetic pathway in mouse cells with professional clarity suitable for publication in scientific journals like Cell or Nature. The use of distinct colors for different transporters enhances visual differentiation between components while maintaining scientific accuracy. The pathway flow is logically depicted with clear directional arrows, and all relevant GO terms and gene identifiers are properly labeled. The cellular compartmentalization is well-represented, showing the plasma membrane, cytosol, and mitochondrial structures. The legend provides helpful context for interpreting the diagram elements.","necessary_changes":null,"optional_changes":null}