Figure: Thiamine diphosphate biosynthetic process 2 (Mouse)¶
This figure illustrates the thiamine diphosphate (TDP) biosynthetic pathway in mouse cells. Thiamine (T) is transported into the cell via the plasma membrane transporters Slc19a2 and Slc19a3. In the cytosol, thiamine is converted to thiamine diphosphate (TDP) by the enzyme Tpk1 (thiamine diphosphokinase). Some TDP is further phosphorylated to thiamine triphosphate (TTP), which is then dephosphorylated back to TDP by Thtpa (thiamine triphosphatase). TDP is transported into the mitochondria via Slc25a19, a mitochondrial thiamine pyrophosphate transporter located in the inner mitochondrial membrane. This pathway plays a critical role in energy metabolism, as TDP is an essential cofactor for several key enzymes involved in carbohydrate metabolism.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the thiamine diphosphate biosynthetic pathway in mouse cells with clear cellular compartmentalization and protein localization. The improved color contrast and added functional descriptions for each protein enhance understanding of the pathway. The movement of thiamine and its phosphorylated derivatives is clearly traced through the cell with appropriate arrows and labels. The detailed legend provides excellent context for interpreting the diagram's symbols and abbreviations.","necessary_changes":null,"optional_changes":null}