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Figure: Vitamin B2 (riboflavin) metabolic process to FAD (Mouse)

id: gomodel:6446bfcb00001336

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The diagram illustrates the vitamin B2 (riboflavin) metabolic pathway to FAD in mouse cells:

  1. Extracellular riboflavin (yellow circle) is transported across the plasma membrane by two transporters:
  2. Slc52a3 (MGI:1916948) - pink rectangular protein

  3. Slc52a2 (MGI:1289288) - pink rectangular protein Both exhibit riboflavin transmembrane transporter activity (GO:0032217)

  4. Riboflavin in the cytosol undergoes a two-step conversion process:

a. Phosphorylation (light blue background): - Rfk (Riboflavin Kinase, MGI:1914688) catalyzes the phosphorylation of riboflavin - Function: Riboflavin kinase activity (GO:0008531) - This reaction converts riboflavin to FMN (Flavin Mononucleotide, green circle) using ATP

b. Adenylylation (light purple background): - Flad1 (Flavin Adenine Dinucleotide Synthetase 1, MGI:2443030) catalyzes the adenylylation of FMN - Function: FMN adenylyltransferase activity (GO:0003919) - This reaction converts FMN to FAD (Flavin Adenine Dinucleotide, pink circle, CHEBI:16238) using ATP

The entire pathway is part of the biosynthetic process (GO:0009058) and occurs within specific cellular compartments: - Transport occurs at the plasma membrane (GO:0005886) - The enzymatic reactions occur in the cytosol (GO:0005829)

This diagram faithfully represents the GO-CAM model (gomodel:6446bfcb00001336) describing the vitamin B2 metabolic process to FAD in mouse.

Feedback from AI on figure:

{"feedback":"The diagram effectively illustrates the vitamin B2 metabolic pathway in a clear, scientifically accurate manner suitable for publication in a high-impact journal. The workflow is logically organized, showing the sequential process from extracellular riboflavin transport across the plasma membrane to the two-step enzymatic conversion in the cytosol resulting in FAD production. The cellular compartments are clearly delineated, and the involved proteins, substrates, and products are distinctly represented with appropriate labels and identifiers.","necessary_changes":null,"optional_changes":"For additional sophistication, you could add a metabolite legend showing molecular structures of riboflavin, FMN, and FAD, or incorporate a small 3D representation of the protein structures if available in the scientific literature."}