Figure: Smog GPCR signaling, epithelial tube formation (D.mel)¶
This pathway diagram depicts the GPCR signaling cascade involved in epithelial tube formation in Drosophila melanogaster. The signaling begins in the extracellular space with Fog protein (FBgn0000719) acting as a receptor ligand, which activates the Smog G protein-coupled receptor (FBgn0051660) on the plasma membrane. This activation triggers a signaling cascade in the cytosol involving Cta G protein (FBgn0000384), followed by Rho1 GTPase (FBgn0014020), then Rok protein kinase (FBgn0026181), and finally Sqh ATPase activator (FBgn0003514). This signaling pathway ultimately leads to apical constriction (GO:0003383), a critical process in epithelial tube formation. Each protein is colored according to its molecular function as indicated in the legend.
Feedback from AI on figure:
{"feedback":"The drawing effectively represents the GPCR signaling pathway in epithelial tube formation in Drosophila melanogaster. It clearly segments the diagram into the extracellular space, plasma membrane, and cytosol, aiding in understanding the spatial context of the signaling events. Each component, from the Fog protein to Sqh, is labeled with their respective activities, facilitating easy comprehension of the pathway sequence. The use of color differentiation for each protein and pathway step enhances clarity, and the use of arrows correctly indicates the direction of signal flow. The final outcome, apical constriction, is distinctively marked, providing a clear end point of the pathway.","necessary_changes":null,"optional_changes":"Consider adding a brief legend or key to explain the meaning of the arrow types or colors used for different protein activities."}