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Figure: BMP7 signaling leading to osteoblast differentiation (Human)

id: gomodel:645d887900000999

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The drawing depicts the BMP7 signaling pathway leading to osteoblast differentiation in humans. In this pathway:

  1. BMP7 (bone morphogenetic protein 7), shown as a pink circle in the extracellular space, acts as a growth factor.

  2. BMP7 binds to and activates type II (ACVR2A) and type I (ACVR1) receptors on the plasma membrane, represented as blue rectangles.

  3. Activated receptors phosphorylate and activate R-SMAD proteins (SMAD1, SMAD5, and SMAD9), shown as green circles in the cytoplasm.

  4. Activated SMADs translocate to the nucleus where they bind to chromatin (brown wavy line).

  5. SMAD proteins function as transcription factors, initiating the expression of genes that drive osteoblast differentiation.

The entire process is part of the BMP signaling pathway (GO:0030509), which ultimately leads to osteoblast differentiation (GO:0001649).

Feedback from AI on figure:

{"feedback":"The drawing effectively illustrates the BMP7 signaling pathway leading to osteoblast differentiation with excellent clarity and scientific accuracy. It captures the key components from the GO-CAM model while presenting them in a visually appealing format suitable for publication in high-impact journals like Cell or Nature.\n\nKey strengths:\n- Clear cellular compartmentalization showing extracellular space, plasma membrane, cytoplasm, and nucleus\n- Logical flow of signaling events from BMP7 binding to transcriptional activation\n- Appropriate visual representation of different protein types (ligand, receptors, transcription factors)\n- Well-labeled components and numbered pathway steps to aid comprehension\n- Simple but effective color coding to distinguish different molecular components\n- Balanced level of detail that maintains scientific accuracy without overwhelming the viewer\n\nThe accompanying legend provides concise explanations that complement the visual elements without redundancy.","necessary_changes":null,"optional_changes":null}