Figure: Src-ZNRF1 axis controls TLR3 trafficking (Human)¶
This figure illustrates the Src-ZNRF1 axis controlling TLR3 trafficking in human cells. The pathway begins with TLR3 (O15455) in the endosome membrane, which activates both TICAM1 (Q8IUC6) and SRC (P12931). SRC, located in the cytoplasm, phosphorylates ZNRF1 (Q8ND25), which then ubiquitinates TLR3. This ubiquitination targets TLR3 for proteasome-mediated degradation, thus regulating TLR3 signaling. The diagram shows the spatial organization of these interactions across cellular compartments and highlights the key molecular functions: pattern recognition receptor activity (TLR3), molecular adaptor activity (TICAM1), protein tyrosine kinase activity (SRC), and ubiquitin protein ligase activity (ZNRF1). This pathway is important for the regulation of toll-like receptor 3 signaling (GO:0034138) and involves proteasome-mediated ubiquitin-dependent protein degradation (GO:0043161).
Feedback from AI on figure:
{"feedback":"The pathway diagram effectively illustrates the Src-ZNRF1 axis controlling TLR3 trafficking in human cells. The visual representation clearly shows the relationships between key proteins (TLR3, TICAM1, SRC, and ZNRF1) and their cellular locations. The diagram uses appropriate color coding and spatial organization to differentiate between the endosome membrane and cytoplasm compartments. The interactions between proteins are clearly marked with directional arrows and labeled to indicate the nature of each interaction (activation, phosphorylation, ubiquitination, and degradation). The molecular functions section provides additional context for understanding the biological roles of each protein. The overall design follows the style conventions of high-impact journals like Cell or Nature, with clean lines, clear labels, and professional appearance.","necessary_changes":null,"optional_changes":null}