Skip to content

Figure: Coenzyme A catabolic process 2 (Mouse)

id: gomodel:645d887900001551

img

This diagram illustrates the Coenzyme A catabolic process in mouse intestinal epithelial cells. The pathway consists of four enzymatic steps:

  1. ALPI (intestinal alkaline phosphatase) dephosphorylates Coenzyme A to produce 3'-dephospho-CoA
  2. ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1) cleaves a pyrophosphate bond in 3'-dephospho-CoA to form D-pantetheine 4'-phosphate
  3. PANK4 (pantothenate kinase 4) removes the phosphate group from D-pantetheine 4'-phosphate to produce pantetheine
  4. VNN1 (vanin 1) hydrolyzes pantetheine into two final products: (R)-pantothenate and cysteaminium

The diagram shows each enzyme with its molecular function annotation (GO term), and each metabolite with its CHEBI identifier. The process takes place within intestinal epithelial cells (CL:0000066) in the intestine (EMAPA:32874), with cellular compartmentation clearly indicated.

Feedback from AI on figure:

{"feedback":"The diagram effectively represents the Coenzyme A catabolic process in mice with clear scientific accuracy and visual clarity. The pathway is illustrated as a sequential flow of enzymatic reactions, with each enzyme (ALPI, ENPP1, PANK4, and VNN1) clearly labeled along with their respective functions. The metabolites are presented in appropriate sequence, from Coenzyme A through intermediates to the final products.\n\nKey strengths include:\n1. Cellular context is well represented, with clear delineation between the intestinal epithelial cell and extracellular space\n2. Each molecule and enzyme is properly identified with both common names and standardized identifiers (CHEBI, GO terms)\n3. The directional flow of the pathway is intuitive and easy to follow\n4. The color coding and legend enhance readability and understanding\n5. Font sizes have been increased for better visibility in presentation contexts\n6. The process description provides additional details that complement the visual elements\n\nThe diagram maintains the scientific integrity of the GO-CAM while presenting it in a visually appealing format suitable for publication in high-tier scientific journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}