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Figure: Canonical mTORC1 signaling (Human)

id: gomodel:646ff70100000391

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This diagram illustrates the canonical mTORC1 signaling pathway in humans, showing how nutrient sensing leads to the regulation of protein synthesis. Key components include:

  • LAMTOR1: Functions as a protein-membrane adaptor at the lysosomal membrane
  • Ragulator complex (GO:0071986): Acts as a guanyl-nucleotide exchange factor (GEF)
  • Rag GTPases (RRAGA/RRAGC): Bind GTP/GDP and recruit mTORC1 to the lysosomal membrane
  • RHEB: Activates mTORC1 kinase activity
  • mTORC1: Central kinase complex containing mTOR and regulatory associated protein RPTOR
  • S6K (RPS6KB1/2): Phosphorylates ribosomal protein S6 (RPS6)
  • 4E-BP1 (EIF4EBP1): When phosphorylated by mTORC1, releases translational repression of eIF4E
  • RPS6: Ribosomal protein involved in cytoplasmic translation

This pathway is essential for cellular growth and metabolism in response to nutrient availability. The diagram shows the spatial organization with events occurring at the lysosomal membrane and ultimately affecting protein synthesis at the ribosome.

Feedback from AI on figure:

{"feedback":"The final drawing clearly illustrates the canonical mTORC1 signaling pathway in humans. The diagram effectively demonstrates the progression from nutrient sensing at the lysosomal membrane through to the regulation of protein synthesis. Key components are distinct and well-labeled, with consistent formatting and appropriate color coding that enhances understanding of different molecular types (complexes, GTPases, kinases, and substrates).\n\nThe improved text size and weight make all components and interactions easily readable. The pathway flow is logically structured, with clear directional arrows and descriptive labels for each interaction (e.g., \"Adaptor,\" \"GEF,\" \"Recruit,\" \"Phosphorylate\"). The addition of annotations explaining the pathway significance and the relationship between 4E-BP1 and eIF4E provides valuable context.\n\nThe legend is comprehensive and clearly identifies all visual elements, including the notation for implicit components not in the source model. The overall layout effectively balances scientific accuracy with visual clarity, making it suitable for inclusion in a journal publication.","necessary_changes":null,"optional_changes":null}