Figure: SMAD6 arginine methylation inhibits SMAD1 signaling (Human)¶
This diagram illustrates the BMP signaling pathway showing how SMAD6 arginine methylation inhibits SMAD1 signaling in humans.
Key components: - BMP4: A bone morphogenetic protein with cytokine activity in the extracellular space - PRMT1: Protein arginine N-methyltransferase 1 located in the cytoplasm - SMAD6: An inhibitory SMAD protein in the cytoplasm that acts via protein sequestering activity when methylated - SMAD4: A co-SMAD protein in the nucleus that acts as a transcription activator - SMAD1: A receptor-regulated SMAD in the nucleus with DNA-binding transcription factor activity
The pathway shows: 1. BMP4 activates PRMT1 via cytokine activity 2. PRMT1 methylates SMAD6 (indicated by the red "M" symbol) 3. Methylated SMAD6 inhibits SMAD1 signaling through protein sequestering 4. SMAD4 normally activates SMAD1 transcription factor activity 5. SMAD1 functions as a DNA-binding transcription factor in the nucleus
This pathway is part of the broader BMP signaling pathway regulating various developmental and cellular processes.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the SMAD6 arginine methylation inhibiting SMAD1 signaling pathway within the context of the BMP signaling pathway. The cellular compartmentalization is clearly defined, showing the extracellular space, cytoplasm, and nucleus. All key proteins (BMP4, PRMT1, SMAD6, SMAD4, and SMAD1) are prominently displayed with appropriate shapes and colors, making it easy to distinguish between them. The pathway connections are well-represented with different arrow styles for activation and inhibition. The addition of molecular function descriptions under each interaction (e.g., 'cytokine activity', 'protein sequestering') provides valuable context. The methylation symbol is clearly marked and explained in the legend. The overall layout follows standard scientific figure conventions suitable for journal publication, with a clear title and comprehensive legend.","necessary_changes":null,"optional_changes":null}