Figure: HCMV UL138 substains STAT1 activation during viral latency (Human-Cytomegalovirus)¶
This diagram illustrates how the Human Cytomegalovirus (HCMV) protein UL138 sustains STAT1 activation during viral latency. The pathway shows UL138 (F5HGQ8) in the Golgi membrane positively regulating WDR48 (Q8TAF3) in the cytoplasm, which activates USP1 (O94782) in the nucleus. USP1, through its deubiquitinase activity, positively regulates STAT1 (P42224), which then binds to DNA as a transcription factor to influence the JAK-STAT signaling pathway. Each protein is color-coded according to its location and origin (viral vs. human), and the interactions are indicated by arrows with labeled mechanisms of regulation.
Feedback from AI on figure:
{"feedback":"The diagram successfully captures the GO-CAM pathway showing how HCMV UL138 sustains STAT1 activation during viral latency. The illustration clearly displays the spatial organization across cellular compartments (Golgi membrane, cytoplasm, and nucleus) and the flow of molecular interactions from UL138 to STAT1. The color coding effectively distinguishes between viral and human proteins, and between proteins in different cellular locations. The interaction labels are now bolded and have background highlights for improved readability, and the additional contextual note in the legend helps readers understand the biological significance of the pathway. The diagram maintains the scientific accuracy required for a journal like Cell or Nature while presenting the information in a visually appealing and easily interpretable format.","necessary_changes":null,"optional_changes":null}