Figure: IL33-signaling pathway (Human)¶
The diagram illustrates the IL33-signaling pathway in humans. The pathway begins with IL33 (a cytokine) in the extracellular space, which binds to the IL1RL1 receptor and IL1RAP co-receptor on the plasma membrane. This binding triggers a signaling cascade in the cytoplasm, where MYD88 acts as a molecular adaptor, recruiting IRAK4 and IRAK1 (protein serine/threonine kinases). IRAK1 then activates TRAF6 (a ubiquitin protein ligase), which leads to the activation of MAP3K7 (a MAP kinase). This pathway is involved in inflammatory responses and is represented according to the Gene Ontology Causal Activity Model (GO-CAM).
Feedback from AI on figure:
{"feedback":"The diagram effectively represents the IL33-signaling pathway as described in the GO-CAM model. It clearly depicts the spatial organization (extracellular space, plasma membrane, cytoplasm) and the sequential flow of signaling from IL33 through the receptors and downstream effectors. The color coding and symbols for different molecular entities (cytokines, receptors, adaptors, kinases, ubiquitin ligases) enhance readability and visual comprehension, supported by the comprehensive legend. The molecular functions are accurately labeled, and the pathway flow is intuitive to follow.","necessary_changes":null,"optional_changes":null}