Figure: Biotin Metabolic Process 1 (Mouse)¶
This figure illustrates the biotin metabolic pathway in mouse cells based on a GO-CAM model. Extracellular biotin (orange circle) is transported across the plasma membrane by Slc5a6 (sodium-dependent multivitamin transporter), which requires sodium ions (light blue circle) and is activated by Pdzd11 (green rectangle). Once inside the cell, biotin serves as an input for Hlcs (biotin-[biotin carboxyl-carrier protein] ligase, pink rectangle), which positively regulates two downstream carboxylases: Acaca (acetyl-CoA carboxylase) and Pcx (pyruvate carboxylase, purple rectangles). Pcx activity is part of the gluconeogenesis process. The diagram shows the spatial organization of these components and their functional relationships within the biotin metabolic process.
Feedback from AI on figure:
{"feedback":"The diagram clearly illustrates the biotin metabolic pathway in mouse cells with excellent visual clarity and scientific accuracy. The strengths include:\n\n1. Clear spatial organization showing extracellular space, plasma membrane, and cytosol\n2. Logical flow of the pathway from biotin intake to downstream regulation\n3. Color-coded proteins and processes with a comprehensive legend\n4. Distinctly colored interaction arrows to differentiate types of relationships\n5. Proper labeling of all components and processes\n\nThe diagram effectively represents the GO-CAM model data while maintaining the visual style appropriate for a high-impact scientific journal. The organization of cellular compartments, protein interactions, and metabolic processes creates an intuitive visualization that would help readers understand the biotin metabolic pathway.","necessary_changes":null,"optional_changes":null}