Figure: Molybdopterin Cofactor Biosynthetic Process 1 (Mouse)¶
This figure illustrates the Molybdopterin Cofactor Biosynthetic Process in mouse cells (GO:0032324), showing the sequential activities of key proteins in the cytosol. The pathway begins with Mocs1 (MGI:MGI:1928904) providing S-adenosyl-L-methionine binding activity, which directly inputs to Mocs2 (MGI:MGI:1336894) with its molybdopterin synthase activity. Mocs2 is positively regulated by Nfs1 (MGI:MGI:1316706), which provides cysteine desulfurase activity, and Mocs2 positively regulates Mocs3 (MGI:MGI:1916622) with its sulfurtransferase activity. Mocs3 provides direct input for Gphn (MGI:MGI:109602), which exhibits molybdopterin molybdotransferase activity and subsequently provides direct input for Mocos (MGI:MGI:1915841) with its molybdenum cofactor sulfurtransferase activity. All these molecular interactions collectively contribute to the molybdopterin cofactor biosynthetic process, which is essential for the formation of molybdenum-containing enzymes.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the Molybdopterin Cofactor Biosynthetic Process in mouse cells with clear visual organization. Each protein is distinctly represented with its associated molecular function, and the relationships between proteins are well-defined using appropriate arrows and annotations. The pathway flow is logically presented, making it easy to follow the sequential steps in the biosynthetic process. The addition of human-readable relationship terms alongside their RO codes enhances clarity for readers unfamiliar with ontology identifiers. The color coding of different proteins aids in visual distinction, and the consistent styling creates a professional appearance suitable for publication in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}