Figure: Glyceraldehyde-3-phosphate biosynthetic process 1 (Mouse)¶
This pathway diagram illustrates the glyceraldehyde-3-phosphate biosynthetic process in mouse cells (GO-CAM: gomodel:6494e2e900002018).
The drawing shows the spatial organization across cellular compartments: - Mitochondrion (yellow compartment): Contains the first steps of the pathway with Pcx and Mdh2 - Mitochondrial inner membrane: Contains the malate transporter Slc25a10 - Cytosol (outer area): Contains most of the pathway enzymes
The pathway flows through these key steps: 1. In mitochondrial matrix: Pyruvate is carboxylated by Pcx to form oxaloacetate, which is converted to malate by Mdh2 2. Malate is transported across the mitochondrial inner membrane by Slc25a10 3. In cytosol: Malate is converted back to oxaloacetate by Mdh1, then to PEP by Pck1 4. PEP undergoes sequential conversions through Eno1, Pgam1, and Pgk1 5. Gapdh converts 1,3-BPG to glyceraldehyde-3-phosphate (G3P) 6. G3P can be isomerized to DHAP by Tpi1, which can be converted to glycerol-3-P by Gpd1
The color-coding scheme differentiates enzyme locations (blue for mitochondrial, purple for cytosolic, and teal for transporters), and red text indicates metabolic intermediates.
This representation faithfully captures the GO-CAM model content while utilizing a visual style appropriate for publication in high-impact scientific journals.
Feedback from AI on figure:
{"feedback":"The pathway diagram effectively illustrates the glyceraldehyde-3-phosphate biosynthetic process in mouse cells with excellent clarity and scientific precision. The subcellular compartmentalization is particularly well-executed, with clear visual differentiation between the mitochondrial matrix, inner membrane, and cytosol.\n\nThe enzyme nodes are appropriately sized and labeled with both gene symbols and functional descriptions, making the diagram immediately informative to viewers familiar with either nomenclature system. The directional flow of the pathway is logically arranged and easy to follow through the reaction arrows.\n\nThe inclusion of metabolic intermediates adds significant value by providing context for each enzymatic step. The color-coding system effectively distinguishes between different types of components (enzymes by location and metabolites), and the comprehensive legend and abbreviations section ensures clarity for all elements in the diagram.\n\nOverall, this is a publication-quality pathway representation that effectively communicates the complex biological process in a visually appealing and scientifically accurate manner.","necessary_changes":null,"optional_changes":null}