Figure: Skeletal muscle acetylcholine-gated channel clustering 1 (Mouse)¶
This diagram illustrates the molecular pathway for skeletal muscle acetylcholine-gated channel clustering in mice. Extracellular Agrin serves as a ligand, binding to LRP4 receptors at the postsynaptic membrane. LRP4 functions as a co-receptor to activate MuSK (Muscle-Specific Kinase), which phosphorylates DOK7. Upon activation, DOK7 recruits adaptor proteins CRK and CRKL, which initiate downstream signaling. CRK/CRKL activate FNTA (Farnesyltransferase alpha) and FARP1 (FERM, RhoGEF and pleckstrin domain-containing protein 1), leading to RAC1 activation through distinct mechanisms: FNTA acts as a protein geranylgeranyltransferase, while FARP1 functions as a guanyl-nucleotide exchange factor (GEF). Activated RAC1 promotes acetylcholine receptor (AChR) clustering, with RAPSN (Receptor-Associated Protein of the Synapse) serving as a crucial adaptor protein that organizes the acetylcholine receptors at the postsynaptic membrane. This pathway is essential for proper neuromuscular junction development and function.
Feedback from AI on figure:
{"feedback":"This diagram effectively captures the signaling pathway responsible for skeletal muscle acetylcholine receptor clustering based on the GO-CAM model provided. The illustration uses appropriate scientific visualization conventions with clear cellular compartmentalization (extracellular space, muscle fiber, and postsynaptic membrane), distinct protein representations, and directional arrows showing the flow of signaling events. The labeled interactions and color-coded protein types enhance readability, while the comprehensive legend helps interpret the diagram's components.","necessary_changes":null,"optional_changes":null}