Figure: Positive regulation of acetylcholine receptor transcription (Mouse)¶
This figure illustrates the positive regulation of acetylcholine receptor transcription in mice. The pathway begins in the extracellular space with Neuregulin-1 (Nrg1) binding to the ErbB2/ErbB3 receptor complex at the postsynaptic membrane. This receptor activation triggers a MAPK signaling cascade, beginning with Raf1 (MAPKKK), which activates Map2k1/Map2k4 (MAPKK), leading to Mapk8 (MAPK/JNK) activation. Activated Mapk8 translocates to the nucleus where it activates the transcription factor Gabpa. Gabpa then promotes transcription of the Chrne gene, which encodes the acetylcholine receptor subunit. The newly synthesized acetylcholine receptor is subsequently transported to the postsynaptic membrane, completing the positive feedback loop.
Feedback from AI on figure:
{"feedback":"The diagram effectively depicts the GO-CAM pathway of positive regulation of acetylcholine receptor transcription in mouse with excellent visual clarity and scientific accuracy. The cellular compartments (extracellular space, postsynaptic membrane, cytoplasm, and nucleus) are clearly delineated, creating an accurate representation of the spatial organization of the signaling cascade. Each protein component is distinctly represented with different shapes and colors, making them easily distinguishable. The orange arrows clearly indicate the flow of signaling, and the process labels at key points help guide the viewer through the pathway steps. The MAPK cascade components (Raf1, Map2k1/4, and Mapk8) are differentiated by varying blue/purple tones, helping distinguish between the kinase levels while maintaining a cohesive visual theme. The addition of a comprehensive legend allows for easy identification of all pathway components.","necessary_changes":null,"optional_changes":null}