Figure: cGAS-STING signaling in the nucleus (Human)¶
This diagram illustrates the cGAS-STING signaling pathway in human cells, focusing on nuclear events. The pathway begins when cyclic GMP-AMP synthase (cGAS, Q8N884) binds to double-stranded DNA in the nucleus and forms molecular condensates. This interaction enables cGAS to synthesize 2',3'-cyclic GMP-AMP (cGAMP), a second messenger that travels to the endoplasmic reticulum (ER) membrane. At the ER membrane, cGAMP binds to Stimulator of Interferon Genes protein (STING1, Q86WV6), which then translocates to the ER-Golgi intermediate compartment membrane. In this location, STING1 acts as a signaling adaptor that activates TANK-binding kinase 1 (TBK1, Q9UHD2) in the cytosol. Activated TBK1 then promotes both the activation of the innate immune response and the positive regulation of type I interferon production. All molecular functions, cellular locations, and biological processes are labeled with their Gene Ontology (GO) identifiers.
Feedback from AI on figure:
{"feedback":"The final drawing effectively captures the cGAS-STING signaling pathway as described in the GO-CAM model. The illustration clearly shows the progression from cGAS binding to DNA in the nucleus, through condensate formation and cGAMP synthesis, to STING1 activation and the subsequent immune response signaling. The use of distinct colors and shapes for different proteins helps distinguish the key players in the pathway, while the cellular compartmentalization (nucleus, ER membrane, ER-Golgi intermediate compartment, and cytosol) provides important spatial context. The added legend for arrows improves understanding of the signaling dynamics.","necessary_changes":null,"optional_changes":null}