Figure: Positive regulation of cGAS-STING signaling by TRIM56 (Human)ΒΆ
This illustration depicts the positive regulation of cGAS-STING signaling by TRIM56 in humans. TRIM56 (Q9BRZ2) acts as a ubiquitin protein ligase (GO:0061630) that monoubiquitinates cGAS (Q8N884). cGAS has three key activities: double-stranded DNA binding (GO:0003690), molecular condensate scaffold activity (GO:0140693) that leads to phase separation, and 2',3'-cyclic GMP-AMP synthase activity (GO:0061501) producing cGAMP. When cytosolic DNA is detected, cGAS binds to it and forms condensates, which enhances its enzymatic activity to produce cGAMP. cGAMP activates STING (not explicitly mentioned in the GO-CAM), which ultimately leads to positive regulation of innate immune response. This pathway is a critical component of cellular defense against cytosolic DNA that may indicate viral infection or cellular damage.
Feedback from AI on figure:
{"feedback":"This pathway diagram clearly illustrates the positive regulation of cGAS-STING signaling by TRIM56 in humans. The visual representation faithfully captures the key components and interactions described in the GO-CAM model while presenting them in a format suitable for publication in high-impact scientific journals.\n\nThe diagram effectively shows:\n1. TRIM56's ubiquitin protein ligase activity leading to monoubiquitination of cGAS\n2. The three key activities of cGAS: dsDNA binding, molecular condensate formation, and cGAMP synthesis\n3. The relationship between these components in the cGAS/STING signaling pathway\n\nThe use of distinct visual elements (colors, shapes, and line styles) helps differentiate between proteins, activities, and types of interactions. The inclusion of Gene Ontology IDs provides valuable reference information without cluttering the main visual elements.\n\nElements not explicitly in the source GO-CAM (STING and the downstream innate immune response) are appropriately marked with dashed lines, maintaining accuracy while providing necessary context for understanding the pathway.","necessary_changes":null,"optional_changes":null}