Figure: Inhibition of cGAS-STING signaling in the nucleus by BANF1 (Human)¶
This figure illustrates the inhibition of cGAS-STING signaling by BANF1 in the human nucleus. The pathway diagram shows how BANF1 (O75531) inhibits cGAS (Q8N884) by preventing it from binding to double-stranded DNA in the nucleus. When active, cGAS synthesizes 2',3'-cyclic GMP-AMP (cGAMP), which then binds to STING1 (Q86WV6) in the ER-Golgi intermediate compartment membrane. Activated STING1 functions as a signaling adaptor that activates TBK1 (Q9UHD2) in the cytosol. TBK1, through its protein kinase activity, promotes the production of Type I interferons, a key component of the innate immune response.
Feedback from AI on figure:
{"feedback":"The diagram clearly illustrates the inhibition of cGAS-STING signaling pathway by BANF1 in human cells. The visual organization effectively separates the three cellular compartments (nucleus, ER-Golgi intermediate compartment, and cytosol) with appropriate visual cues including color differentiation and subtle shadows to enhance depth. \n\nThe molecular interactions are presented in a logical flow, with well-labeled proteins and their respective activities. Each key component of the pathway (BANF1, cGAS, STING1, and TBK1) is clearly marked with both gene names and UniProt identifiers, making the diagram scientifically precise while remaining visually accessible.\n\nThe use of color-coded activity labels helps distinguish the different functional roles within the pathway, and the inclusion of a comprehensive legend enhances understanding of the interaction types and molecular representations. The text annotations are sized appropriately for readability in a journal figure format.","necessary_changes":null,"optional_changes":null}