Skip to content

Figure: Activation of cGAS-STING signaling following acetylation by KAT5 (Human)

id: gomodel:64d5781900000111

img

Figure Legend: Activation of cGAS-STING signaling via KAT5-mediated acetylation

This pathway diagram illustrates the molecular mechanisms underlying the activation of cGAS-STING signaling in human cells, beginning with acetylation of cGAS by KAT5.

The process occurs within the nucleus (GO:0005634) and involves the following sequential steps:

  1. KAT5 (UniProtKB:Q92993-4) acetylates inactive cGAS (UniProtKB:Q8N884) via its peptide-lysine-N-acetyltransferase activity (GO:0061733).

  2. Upon acetylation, cGAS gains double-stranded DNA binding activity (GO:0003690), enabling it to interact with nuclear DNA.

  3. DNA-bound cGAS develops molecular condensate scaffold activity (GO:0140693), allowing it to form phase-separated molecular condensates.

  4. These molecular condensates facilitate cGAS enzymatic function as a 2',3'-cyclic GMP-AMP synthase (GO:0061501), producing the second messenger cGAMP.

This pathway represents a critical component of the cGAS/STING signaling pathway (GO:0140896) and contributes to the positive regulation of innate immune response (GO:0045089).

Feedback from AI on figure:

{"feedback":"This diagram effectively illustrates the activation pathway of cGAS-STING signaling following acetylation by KAT5 in human cells. The visual representation clearly shows the progression from KAT5-mediated acetylation of cGAS to the subsequent activation of cGAS's various molecular functions, all occurring within the nucleus. The different states of cGAS are well-distinguished through color coding and clear labeling.","necessary_changes":null,"optional_changes":"Consider adding a small depiction of cGAMP production and its role in the signaling cascade to complete the pathway visualization."}