Figure: Role of 14-3-3epsilon (YWHAE) in RIGI signaling pathway (Human)¶
This pathway diagram illustrates the role of 14-3-3epsilon (YWHAE) in the RIGI signaling pathway in human cells. The diagram shows four key proteins:
- RIGI (UniProtKB:O95786): A pattern recognition receptor (GO:0038187) located in the cytoplasm
- TRIM25 (UniProtKB:Q14258): An E3 ubiquitin-protein ligase (GO:0061630) located in the cytoplasm
- YWHAE/14-3-3epsilon (UniProtKB:P62258): A signaling adaptor protein (GO:0035591) that interacts with the mitochondrial membrane
- MAVS (UniProtKB:Q7Z434): A signaling adaptor protein (GO:0035591) located at the mitochondrial membrane
The pathway depicts the following interactions: - RIGI positively regulates (RO:0002413) TRIM25 - TRIM25 positively regulates (RO:0002413) YWHAE - YWHAE directly positively regulates (RO:0002629) MAVS
All proteins participate in the cytoplasmic pattern recognition receptor signaling pathway (GO:0002753), which is part of the innate immune response. Different arrow styles indicate distinct types of regulatory relationships between proteins.
Feedback from AI on figure:
{"feedback":"This pathway diagram effectively represents the RIGI signaling pathway with clear, visually distinct elements for different proteins and their interactions. The cellular compartments (cytoplasm and mitochondrial membrane) are well-defined, and the relationships between proteins are illustrated with appropriate visual cues. The color coding and line styles help distinguish between different types of regulatory relationships, and all elements are properly labeled with both common names and GO terms for precise identification. The overall layout follows a logical flow that makes the signaling pathway easy to understand for scientific audiences.","necessary_changes":null,"optional_changes":null}