Figure: Extrinsic apoptotic signaling pathway via death domain receptors 1(Mouse)ΒΆ
This figure illustrates the extrinsic apoptotic signaling pathway via death domain receptors in mouse cells (GO-CAM model: 64e7eefa00001233). The pathway begins when TNF (Tnf) in the extracellular space binds to its receptor TNFR1 (Tnfrsf1a) on the plasma membrane. This activates a signaling cascade in the cytosol where TNFR1 recruits the adaptor protein TRADD (Tradd), which then engages RIPK1 (Ripk1) kinase. TRADD can either directly recruit FADD (Fadd) or do so via RIPK1 (shown by the dashed line). FADD then activates Caspase-8 (Casp8), leading to the execution phase of apoptosis. Each protein is represented according to its molecular function as indicated in the legend, and cellular compartments are clearly demarcated. This pathway represents the positive regulation of execution phase of apoptosis (GO:1900119).
Feedback from AI on figure:
{"feedback":"The drawing effectively illustrates the extrinsic apoptotic signaling pathway via death domain receptors in mice. The pathway flow is clear, showing how TNF binding to TNFR1 initiates a cascade through adaptor proteins (TRADD, FADD) and the kinase RIPK1, ultimately activating Caspase-8 and triggering apoptosis execution. The cellular compartmentalization is well-defined with the extracellular space, plasma membrane, and cytosol clearly labeled. All components from the GO-CAM model are accurately represented with appropriate molecular functions indicated. The addition of a pathway summary and comprehensive legend enhances understanding of the biological process and the meaning of different shapes and colors used in the illustration.","necessary_changes":null,"optional_changes":null}