Figure: TRIM69 activation of STK3 by ubiquitination leading to centrosome separation (Human)¶
This figure illustrates the molecular pathway through which TRIM69 regulates centrosome separation in human cells. The pathway begins with TRIM69, which exhibits ubiquitin ligase activity (GO:0061630) at the centrosome (GO:0005813). TRIM69 ubiquitinates and activates PLK1 (protein serine kinase, GO:0106310), which in turn activates STK3 (protein serine/threonine kinase, GO:0004674). STK3 then activates NEK2 (protein kinase, GO:0004672), which drives the final process of centrosome separation (GO:0051299). All these molecular interactions occur at the centrosome, which is initially shown as a paired structure that separates as the end result of this signaling cascade. The pathway represents protein localization to the centrosome (GO:0071539) and is part of the overall centrosome cycle (GO:0007098).
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the TRIM69-mediated pathway leading to centrosome separation in human cells. The spatial organization clearly shows the sequence of protein activations occurring at the centrosome. Each protein (TRIM69, PLK1, STK3, and NEK2) is distinctly represented with appropriate colors and labels, while the arrows between them clearly indicate the direction of activation. The initial paired centrosomes and their eventual separation are visually represented to show the biological outcome. The diagram includes all key components from the GO-CAM model and presents them in a style appropriate for a high-impact journal publication.","necessary_changes":null,"optional_changes":null}