Figure: Tumor necrosis factor-mediated signaling pathway 2 (Mouse)¶
The diagram depicts the Tumor Necrosis Factor (TNF)-mediated signaling pathway in mice. TNF cytokine (Tnf) in the extracellular space activates its receptor (Tnfrsf1a) on the plasma membrane. This triggers a signaling cascade where receptor activation leads to the sequential involvement of signaling adaptors Nsmaf and Rack1. Rack1 then activates the enzyme activator Eed, which activates the sphingomyelin phosphodiesterase Smpd2, ultimately leading to ceramide metabolism. All components shown are directly from the GO-CAM model, with distinct shapes and colors representing different molecular functions: cytokines (circles), receptors (rectangles), signaling adaptors (diamonds), enzyme activators (rectangles), and enzymes (ovals).
Feedback from AI on figure:
{"feedback":"The diagram effectively outlines the tumor necrosis factor-mediated signaling pathway in mice, capturing all key components and interactions as per the description. The use of distinct colors and shapes aids in differentiating between various pathway elements, such as cytokines, receptors, adaptors, and enzymes. The flow of the pathway is clear and logical, allowing easy understanding of the sequence of activations leading to the ceramide metabolic process. Text is well-aligned and legible, and the addition of a legend further clarifies the meaning of the different shapes and colors used throughout the diagram.","necessary_changes":null,"optional_changes":null}