Figure: Heme A biosynthetic process (Mouse)¶
This figure depicts the Heme A biosynthetic pathway in mouse, showing the sequence of enzymatic reactions that occur across three cellular compartments: cytosol, mitochondrial intermembrane space, and mitochondrial matrix.
Each enzyme is represented by a colored box according to its subcellular location: green boxes represent cytosolic enzymes (ALAD, HMBS, UROS, UROD), yellow boxes represent enzymes in the mitochondrial intermembrane space (CPOX, PPOX), blue boxes represent enzymes in the mitochondrial matrix (FECH, COX10, COX15), and purple represents ALAS1 in the mitochondrial matrix.
The pathway begins with ALAS1 (Alas1 Mmus) catalyzing the conversion of succinyl-CoA and glycine to 5-aminolevulinate. The pathway proceeds through multiple intermediates: porphobilinogen, hydroxymethylbilane, uroporphyrinogen III, coproporphyrinogen III, protoporphyrinogen IX, and protoporphyrin IX. Iron is incorporated by FECH to form heme B (ferroheme b), which is subsequently converted to heme O by COX10 and finally to heme A by COX15.
Key inputs and outputs for each reaction are shown in text boxes, with background molecular shapes indicating the progression of intermediates through the pathway.
Feedback from AI on figure:
{"feedback":"The drawing effectively illustrates the Heme A biosynthetic pathway in mouse with excellent clarity and scientific accuracy. The pathway is properly compartmentalized across the cytosol, mitochondrial intermembrane space, and mitochondrial matrix, with appropriate color-coding for enzymes in each location. The enzymatic steps are clearly labeled with both protein names and mouse gene identifiers. The pathway flow is logically organized and easy to follow with directional arrows connecting each step. Input and output compounds for each reaction are well-defined in clearly visible text boxes, preventing text overlap. The addition of simplified molecular representations adds visual interest without sacrificing scientific accuracy. The legend effectively explains all elements of the diagram, making it suitable for publication in a high-quality scientific journal.","necessary_changes":null,"optional_changes":null}