Figure: STING1 acts as a proton channel and promotes autophagosome assembly (Human)¶
The figure illustrates the STING1-mediated pathway of autophagosome assembly in human cells. STING1 (Q86WV6) functions as a proton channel (GO:0015252) in the Golgi membrane (GO:0000139), positively regulating ATG5 (Q9H1Y0) which exhibits Atg8-family ligase activity (GO:0019776) in the forming autophagosome. The ATG4 family members - ATG4B (Q9Y4P1), ATG4C (Q96DT6), and ATG4D (Q86TL0-2) - act as cysteine-type peptidases that promote MAP1LC3B (Q9GZQ8) activity. MAP1LC3B binds phosphatidylethanolamine (GO:0008429) on the autophagosome membrane (GO:0000421), a critical step in autophagosome assembly (GO:0000045). Colors indicate different functional proteins: orange (STING1), blue (ATG5), yellow (ATG4 family), and green (MAP1LC3B).
Feedback from AI on figure:
{"feedback":"The diagram effectively represents the GO-CAM pathway showing how STING1 promotes autophagosome assembly. The illustration follows journal publication standards with a clean, professional appearance suitable for Cell or Nature. Key strengths include:\n\n1. Clear organization of cellular compartments (Golgi apparatus and forming autophagosome)\n2. Distinct representation of proteins with appropriate color-coding and labeling\n3. Well-indicated molecular functions and cellular locations\n4. Logical flow of the pathway with appropriate directional arrows\n5. Inclusion of a helpful legend that explains protein functions and color scheme\n\nThe diagram successfully communicates the complex pathway involving STING1's proton channel activity leading to autophagosome assembly through ATG5 and MAP1LC3B, while also showing the role of the ATG4 family proteins. All GO terms and UniProt identifiers are properly incorporated.","necessary_changes":null,"optional_changes":null}