Figure: TRIM55 and TRIM21-mediated inhibition of NFKB2 (Human)¶
This figure illustrates the TRIM55 and TRIM21-mediated inhibition of NFKB2 in human cells. In the cytoplasm, TRIM55 (UniProtKB:Q9BYV6) functions as a K48-linked ubiquitin ligase and acts as an adaptor for TRIM21 (UniProtKB:P19474), which serves as a K63-linked ubiquitin ligase. Their combined activity affects VCP (UniProtKB:P55072), which recognizes K48-linked polyubiquitin modifications. VCP then inhibits NFKB2 (UniProtKB:Q00653) in the nucleus, regulating its DNA-binding transcription activator activity. This pathway represents an interaction between canonical NF-κB signal transduction and the positive regulation of non-canonical NF-κB signal transduction. Different shapes represent different proteins and molecular functions: rounded rectangles for TRIM proteins, hexagons for VCP, and polygons for transcription factors. Ubiquitination events are depicted with circles indicating the type of linkage (K48 or K63).
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the TRIM55 and TRIM21-mediated inhibition of NFKB2 in a style suitable for high-impact journals like Cell or Nature. The key strengths include:\n\n1. Clear visual distinction between cellular compartments (cytoplasm and nucleus)\n2. Protein-specific shapes and consistent color coding that enhances recognition\n3. Detailed representation of molecular processes, particularly the different types of ubiquitination (K48 vs K63)\n4. Appropriate use of symbols for different molecular functions (ligase activity, adaptor function, transcriptional activation)\n5. Comprehensive legend that explains all visual elements\n\nThe diagram faithfully represents the GO-CAM model while using visual metaphors that make the biological processes more intuitive. The use of different shapes for different protein functions and distinct symbols for ubiquitination chains helps readers quickly understand the pathway mechanics. The spatial organization effectively conveys the relationship between cytoplasmic events and nuclear transcriptional regulation.","necessary_changes":null,"optional_changes":null}