Figure: TAX1BP1-mediated degradation of MAVS by E3 ligase ITCH (Human)¶
This figure illustrates the TAX1BP1-mediated degradation of MAVS by E3 ligase ITCH in human cells. The pathway occurs within the mitochondrion and involves four key proteins: MAVS (Q7Z434), TAX1BP1 (Q86VP1), ITCH (Q96J02), and TRAF3IP3 (Q9Y228). TAX1BP1 serves as an adaptor protein that recruits the E3 ubiquitin ligase ITCH to MAVS. ITCH then adds K48-linked ubiquitin chains to MAVS, targeting it for degradation. This process negatively regulates the cytoplasmic pattern recognition receptor signaling pathway. MAVS also signals to TRAF3IP3, which acts as a molecular adaptor in this pathway.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the TAX1BP1-mediated degradation of MAVS by E3 ligase ITCH in a clear, journal-quality style. The key improvements in this final version include better text placement with background highlights to prevent overlap with interaction arrows, consistent arrow styling, and improved font sizes for better readability. The mitochondrial setting is clearly indicated, and the roles of each protein are well-defined with appropriate colors and labels. The biological processes are properly annotated, and the legend provides essential information for interpreting the pathway.","necessary_changes":null,"optional_changes":null}