Figure: TRIM32-TAX1BP1-dependent selective autophagic degradation of TICAM1 (Human)¶
This figure illustrates the TRIM32-TAX1BP1-dependent selective autophagic degradation of TICAM1 in the TLR4 signaling pathway. TLR4 receptor in the endosome membrane activates TICAM2, which then activates TICAM1. TICAM1 stimulates IRF3, which translocates to the nucleus to function as a DNA-binding transcription factor. The pathway is negatively regulated by TRIM32, which recruits TAX1BP1 to target TICAM1 for selective autophagy, leading to its degradation and subsequent downregulation of TLR4 signaling.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the TRIM32-TAX1BP1-dependent selective autophagic degradation of TICAM1 pathway. The spatial organization clearly shows the signal transduction from the TLR4 receptor on the endosome membrane through TICAM2 to TICAM1, and ultimately to IRF3 translocation and DNA binding in the nucleus. The negative regulation pathway via TRIM32 and TAX1BP1 targeting TICAM1 for selective autophagy is distinctly visualized with thicker dashed arrows. The diagram's color coding helps distinguish different protein families, and the subcellular compartments (endosome, cytoplasm, nucleus) provide clear context for the pathway's spatial organization. The included legend helps readers interpret the different arrow styles representing activation versus inhibition/degradation processes.","necessary_changes":null,"optional_changes":null}