Figure: LMNA (Lamin-A/C) maturation (Human).¶
This diagram illustrates the maturation process of LMNA (Lamin-A/C) in human cells. The pathway shows how Prelamin A undergoes a series of post-translational modifications to become mature Lamin A/C that incorporates into the nuclear lamina.
The process involves four sequential enzymatic steps: 1. Farnesylation by FNTA (Protein farnesyltransferase alpha) 2. Initial proteolytic cleavage by ZMPSTE24 (Zinc metalloprotease STE24) 3. Methylation by ICMT (Isoprenylcysteine carboxyl methyltransferase) 4. Final proteolytic cleavage by ZMPSTE24
The mature Lamin A/C contributes to nuclear envelope organization (GO:0006998) and serves as a structural constituent of the nuclear lamina (GO:0160123). The entire sequence represents the biological process of protein maturation (GO:0051604).
Color coding in the diagram: - Green boxes: Different forms of the LMNA protein during maturation - Orange boxes: Enzymatic activities and the proteins that perform them - Purple boxes: Biological processes - Blue boxes: Molecular functions - Yellow box: Overall process of protein maturation
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the LMNA maturation pathway in a clear, scientifically accurate manner suitable for publication in journals like Cell or Nature. The sequential process from Prelamin A to mature Lamin A/C is well-represented through a logical flow with appropriate enzymatic steps. The color-coding system helps distinguish between different components (protein forms, enzymatic activities, biological processes, and molecular functions), making the diagram intuitive to follow. The nuclear context is appropriately depicted with the nuclear lamina and envelope clearly indicated. All GO terms and UniProt identifiers are properly labeled, providing necessary scientific reference points. The simplified legend aids in quick interpretation without overwhelming the reader.","necessary_changes":null,"optional_changes":null}