Figure: KSHV-ORF57 inhibition of host P-body formation (Human-HHV8)¶
The diagram depicts the molecular pathway by which KSHV-ORF57 inhibits host P-body formation. The viral protein ORF57 (red circle) enters the host cell from the KSHV virus and sequesters the host adaptor protein TNRC6A (green rectangle). This sequestration disrupts the normal function where TNRC6A enables AGO2's RNA endonuclease activity (blue rectangle) during P-body assembly. As a result, P-body formation is inhibited, which would normally facilitate mRNA degradation and storage. The solid lines represent active interactions (viral entry and sequestration), while dashed lines indicate inhibited pathways. The diagram is consistent with GO-CAM model gomodel:653b0ce600001283 showing this host-virus interaction.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the mechanism of KSHV-ORF57 inhibition of host P-body formation in a clear, professional style suitable for a scientific journal. The visual hierarchy and color coding help distinguish between viral and host components, while the labeled interactions accurately represent the relationships described in the GO-CAM model. The addition of contextual information about P-body function enhances understanding for viewers, and the legend provides clear guidance on interpreting the diagram elements. The representation stays faithful to the source data while presenting the biological pathway in an accessible format.","necessary_changes":null,"optional_changes":null}