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Figure: SQSTM1 mediates retention of KEAP1 into p62 bodies (Human).

id: gomodel:654d809000000171

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This diagram illustrates how SQSTM1 (p62) mediates the retention of KEAP1 into p62 bodies in human cells.

The pathway begins with cellular stress (GO:0033554) activating ULK1 kinase, which phosphorylates SQSTM1/p62 (GO:0004674). Once phosphorylated, SQSTM1/p62 performs two key functions:

  1. It acts as a molecular condensate scaffold (GO:0140693) to form p62 bodies, which are intracellular membraneless organelles (GO:0043232).
  2. It sequesters KEAP1 protein (GO:0140311) and retains it within these p62 bodies.

When KEAP1 is sequestered within p62 bodies, its normal function as a ubiquitin-ligase adaptor (GO:1990756) in the ubiquitin-dependent protein catabolic process (GO:0006511) is inhibited. This sequestration prevents KEAP1 from targeting NFE2L2/Nrf2 for degradation (though NFE2L2 is not explicitly mentioned in the source GO-CAM).

Color coding in the diagram: ULK1 (blue), SQSTM1/p62 (green), KEAP1 (pink), and p62 bodies (yellow). Different arrow styles represent distinct types of interactions: solid lines for direct effects, dashed lines for formation processes, and dash-dotted lines for inhibited functions.

Feedback from AI on figure:

{"feedback":"The diagram effectively illustrates the SQSTM1-mediated pathway for KEAP1 retention in p62 bodies, presenting a clear visual representation suitable for publication in a scientific journal. The visual elements employ appropriate scientific conventions while maintaining artistic quality.\n\nKey strengths:\n- Clear depiction of the cellular stress response triggering ULK1 phosphorylation of SQSTM1/p62\n- Effective visualization of p62 body formation and KEAP1 sequestration\n- Appropriate use of color coding to distinguish different proteins and structures\n- Well-labeled pathway steps with corresponding GO terms\n- Informative legend that clarifies the diagram components\n- Good text contrast and readability\n- Differentiated arrow styles to indicate different types of interactions\n\nThe diagram successfully captures the key components and relationships described in the GO-CAM model while presenting them in a publication-quality figure that would be appropriate for a high-impact journal.","necessary_changes":null,"optional_changes":null}