Figure: Activation of autophagosome assembly by ATM-CHK2-TRIM32-ATG7 axis (Human)¶
ATM: Ataxia Telangiectasia Mutated protein (protein serine/threonine kinase) CHK2: Checkpoint Kinase 2 (protein serine kinase) TRIM32: Tripartite Motif Containing 32 (ubiquitin protein ligase) ATG7: Autophagy Related 7 (Atg12 activating enzyme) P: Phosphorylation Ub-K63: Lysine 63-linked ubiquitination Autophagosome: Double-membrane structure that forms during autophagy
Feedback from AI on figure:
{"feedback":"This pathway diagram effectively portrays the ATM-CHK2-TRIM32-ATG7 axis in autophagosome assembly activation based on the GO-CAM model. The diagram clearly shows the sequence of events from oxidative stress response through ATM activation, CHK2 phosphorylation, TRIM32 ubiquitin ligase activity, and ultimately ATG7's role in autophagosome assembly. The visual representations are both scientifically accurate and visually appealing, with appropriate use of color, shapes, and spatial organization to convey the pathway relationships.","necessary_changes":null,"optional_changes":"The diagram could potentially be enhanced by including more specific information about the subcellular localization of ATM and CHK2, though this wasn't explicitly defined in the source model."}