Figure: USP25-mediated stabilization of KEAP1 leading to NRF2 degradation (Human)¶
This figure illustrates the molecular pathway of USP25-mediated stabilization of KEAP1 leading to NRF2 degradation in human cells. The deubiquitinase USP25 (green) stabilizes KEAP1 (orange) in the cytoplasm. KEAP1 acts as an adaptor for the ubiquitination of NRF2 (red) by RBX1 (blue), leading to NRF2 degradation. This pathway negatively regulates the cellular response to oxidative stress by preventing NRF2 from translocating to the nucleus and activating antioxidant response genes.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the USP25-KEAP1-NRF2 regulatory pathway with clear protein representations and interactions. The cellular compartmentalization (cytoplasm vs. nucleus) helps viewers understand the spatial context of these interactions. The color coding, consistent labeling, and meaningful arrows with descriptive text make the biological process easy to follow. The title, legend, and summary box provide additional context that enhances understanding of this oxidative stress response pathway.","necessary_changes":null,"optional_changes":null}