Figure: PINK1 role in mitophagy (Human)ΒΆ
The diagram illustrates the PINK1 role in mitophagy pathway in human cells. PINK1 (Q9BXM7) is a protein serine/threonine kinase located in the mitochondrion that activates ARHGAP26 (Q9UNA1), which functions as a protein-macromolecule adaptor, also in the mitochondrion. ARHGAP26 subsequently activates ABI2 (Q9NYB9), which has cytoskeletal anchor activity in the cytoplasm. All three proteins collectively contribute to the mitophagy process, represented at the bottom of the diagram.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the PINK1 role in mitophagy with clear visual representation of the pathway. The protein interactions are well-depicted with directional arrows showing how PINK1 leads to ARHGAP26 activation, which then leads to ABI2. The cellular compartments (mitochondrion and cytoplasm) are clearly delineated, helping to show where each activity occurs. The addition of protein IDs and a comprehensive legend enhances the scientific accuracy and interpretability of the figure.","necessary_changes":null,"optional_changes":"For publication in journals like Cell or Nature, you might consider adding molecular details like phosphorylation events or ubiquitination that may be part of this pathway, though these aren't explicitly mentioned in the provided GO-CAM model."}