Figure: Role of USP51 in DNA damage response via DGCR8 deubiquitination (Human)¶
Legend: • ATM (UniProtKB:Q13315): Serine/threonine kinase that acts as a DNA damage sensor • USP51 (UniProtKB:Q70EK9): Cysteine-type deubiquitinase that removes ubiquitin from target proteins • DGCR8 (UniProtKB:Q8WYQ5): Protein that functions as a molecular adaptor in the DNA damage response • RNF168 (UniProtKB:Q8IYW5): E3 ubiquitin ligase that targets histones at sites of DNA damage • H2AC1 (UniProtKB:Q96QV6): Histone protein that becomes ubiquitinated during DNA damage response
Pathway summary: Following DNA double-strand break detection, ATM kinase phosphorylates and activates USP51, which deubiquitinates DGCR8. Active DGCR8 functions as an adaptor protein that promotes RNF168 activity at sites of DNA damage. RNF168 then ubiquitinates histone H2AC1, contributing to chromatin remodeling and DNA repair complex recruitment.
Feedback from AI on figure:
{"feedback":"This pathway diagram effectively illustrates the role of USP51 in the DNA damage response via DGCR8 deubiquitination. The diagram clearly shows the sequence of events: ATM phosphorylates USP51, which deubiquitinates DGCR8, which then activates RNF168, which ubiquitinates histones at the DNA damage site. The use of distinct colors for different proteins helps distinguish their roles, while the clear labeling and appropriate spacing enhance readability. The cellular context is well-represented by showing the nucleus with the site of double-strand break.","necessary_changes":null,"optional_changes":null}