Figure: Ubiquitination of MRE11 by RNF126 promotes its exonuclease activity (Human).¶
This figure illustrates the molecular pathway involved in MRE11 regulation during double-strand break repair in humans. The E3 ubiquitin ligase RNF126 (green) catalyzes K29-linked and K27-linked ubiquitination of MRE11 (blue), which enhances its 3'-5' exonuclease activity at DNA double-strand break sites. Activated MRE11 positively regulates EXO1's 5'-3' exonuclease activity (orange), promoting DNA strand resection as part of the homologous recombination repair pathway. The different colors distinguish the key proteins involved, with RNF126 initiating the signaling cascade that ultimately leads to efficient DNA repair through the coordinated action of MRE11 and EXO1 exonucleases.
Feedback from AI on figure:
{"feedback":"The drawing effectively illustrates the molecular pathway described in the GO-CAM model, showing how RNF126 ubiquitinates MRE11 to promote its exonuclease activity in double-strand break repair. The clear visual hierarchy with distinct protein representations (RNF126, MRE11, and EXO1) makes the pathway easy to follow. The addition of semi-transparent text backgrounds improves readability by separating labels from the pathway elements. Use of different colors, increased font sizes for protein names, and the comprehensive legend all contribute to making this illustration suitable for publication in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}