Figure: Regulation of TLR9 by palmitoylation (Human)¶
The diagram depicts the regulation of TLR9 by palmitoylation in human cells, showing key proteins and their interactions across different cellular compartments:
ZDHHC3 (green): Located in the Golgi apparatus, exhibits palmitoyltransferase activity that adds palmitate groups to proteins, positively regulating UNC93B1.
UNC93B1 (yellow): Acts as a molecular carrier that positively regulates TLR9 by transporting it to the early endosome membrane.
TLR9 (pink): Located in the early endosome membrane, functions as a pattern recognition receptor in the TLR9 signaling pathway.
PPT1 (purple): Located in the lysosomal membrane, exhibits palmitoyl-hydrolase activity that removes palmitate groups, negatively regulating UNC93B1.
Green arrows indicate positive regulation, while red arrows indicate negative regulation. This palmitoylation/depalmitoylation cycle regulates the trafficking and signaling activity of TLR9.
Feedback from AI on figure:
{"feedback":"The final illustration effectively captures the regulation of TLR9 by palmitoylation in a style suitable for publication in scientific journals like Cell or Nature. The diagram presents a clear visual narrative of how ZDHHC3 in the Golgi apparatus positively regulates UNC93B1 through palmitoylation, how UNC93B1 facilitates TLR9 transport to the early endosome where it functions, and how PPT1 in the lysosomal membrane negatively regulates this process through depalmitoylation. The use of cellular compartments, protein representations, and regulatory arrows creates an intuitive and scientifically accurate representation of this biological pathway.","necessary_changes":null,"optional_changes":null}