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Figure: Phosphorylation of NBN regulates DNA repair choice at telomes (Human).

id: gomodel:65a1f4f800002884

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This diagram illustrates how phosphorylation of NBN (Nibrin) regulates DNA repair choice at telomeres in human cells. The pathway shows two main branches:

  1. Protection Pathway (Left): CDK2 (Cyclin-Dependent Kinase 2) phosphorylates NBN, which then uses its chromatin-protein adaptor activity to interact with TERF2 (Telomeric Repeat-Binding Factor 2). This leads to protection from non-homologous end joining (NHEJ) at telomeres.

  2. Repair Pathway (Right): PPP1CA (Protein Phosphatase 1 Catalytic Subunit Alpha) dephosphorylates NBN, which then interacts with TERF2 through its adaptor activity. This promotes alternative non-homologous end joining (Alt-NHEJ) DNA repair.

Both pathways involve TERF2 binding to telomeric DNA and contribute to telomere maintenance in response to DNA damage. Phosphorylation status of NBN acts as a molecular switch determining which DNA repair pathway is used at telomeres.

Feedback from AI on figure:

{"feedback":"The diagram effectively illustrates the phosphorylation of NBN and its role in regulating DNA repair choice at telomeres. The visual representation includes all key components from the GO-CAM model while maintaining clarity and scientific accuracy.\n\nThe diagram's strengths include:\n- Clear color-coding to distinguish between the protection and repair pathways\n- Appropriate use of shapes to represent different proteins and processes\n- Inclusion of all relevant GO terms and UniProt identifiers\n- Well-structured layout showing the nuclear context and telomeric region\n- Informative legend explaining abbreviations and terminology\n- Enhanced readability with appropriate font sizes and line weights\n\nThe diagram successfully captures the molecular mechanisms described in the GO-CAM model, showing how CDK2 phosphorylates NBN leading to protection from NHEJ, while PPP1CA dephosphorylates NBN leading to alternative NHEJ repair, with both pathways involving TERF2 interaction with telomeric DNA.","necessary_changes":null,"optional_changes":null}