Figure: Cell contact inhibition by Hippo signaling (Human).¶
This figure illustrates the Cell Contact Inhibition pathway mediated by Hippo signaling in human cells. Upon cell-cell contact, adaptor proteins NF2 and WWC2 initiate the signaling cascade by activating SAV1 (kinase activator), which then activates STK3 (kinase). STK3 subsequently activates LATS2 (kinase), which phosphorylates YAP1. Phosphorylated YAP1 is sequestered in the cytoplasm by YWHAB, preventing its translocation to the nucleus. When YAP1 is not sequestered, it can translocate to the nucleus where it functions as a transcription coregulator. This pathway plays a crucial role in regulating cell growth and proliferation in response to cell density and contact inhibition.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the Hippo signaling pathway with clear organization and visual hierarchy. The cellular compartments (cytoplasm and nucleus) are distinctly defined, and the protein interactions are represented with appropriate symbols and connections. The color coding helps distinguish between different functional classes of proteins (adaptors, kinases, etc.), and the labeled arrows clearly indicate the direction and nature of interactions (activation, phosphorylation, translocation). The background boxes for process labels ensure readability, and the added title and GO term explanation enhance overall clarity.","necessary_changes":null,"optional_changes":null}