Figure: Hippo signaling positive regulation by TAZ cytoplasmic retention (Human).¶
This figure illustrates the Hippo signaling pathway with a focus on TAZ (WWTR1) cytoplasmic retention in human cells. The pathway begins with adaptor proteins SAV1 and WWC1 activating the STK3/4 kinases. These kinases then phosphorylate and activate LATS1/2 kinases. LATS1/2 phosphorylate YWHAE (14-3-3ε protein), which then sequesters the transcriptional co-activator WWTR1 (TAZ) in the cytoplasm, preventing its translocation to the nucleus. When in the nucleus, WWTR1 functions as an active transcriptional co-regulator. This cytoplasmic retention mechanism represents a key aspect of positive regulation of Hippo signaling, as it prevents TAZ-mediated transcriptional activity.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the Hippo signaling pathway focusing on TAZ cytoplasmic retention. The use of distinct cellular compartments (cytoplasm and nucleus) creates a clear spatial context for the pathway. The protein interactions are presented with bold, directional arrows that communicate the signaling flow well. Color-coding of different protein types (adaptors, kinases, sequestering proteins, and transcriptional co-activators) helps the viewer quickly understand the functional roles within the pathway. Text labels are appropriately sized and positioned for readability. The phosphorylation mark is clearly indicated, and the inhibitory effect on nuclear translocation is shown with appropriate graphical elements. The comprehensive legend explains all components and ensures the figure is self-explanatory.","necessary_changes":null,"optional_changes":null}