Figure: Regulation of GSK3B phosphorylation by ZDHHC4-mediated palmitoylation (Human)¶
This figure illustrates the regulation of GSK3B phosphorylation by ZDHHC4-mediated palmitoylation in human cells. ZDHHC4 in the endoplasmic reticulum exhibits palmitoyltransferase activity (GO:0016409) that positively regulates AKT1 in the cytoplasm. AKT1 has protein serine/threonine kinase activity (GO:0004674) that negatively regulates GSK3B, also found in the cytoplasm. GSK3B exhibits protein serine/threonine kinase activity that negatively regulates EZH2 located on chromosomes, which has histone methyltransferase activity (GO:0042054). Within this pathway, AKT1 and EZH2 contribute to positive regulation of cell migration (GO:0030335), while GSK3B participates in negative regulation of cell migration (GO:0030336).
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the regulation of GSK3B phosphorylation by ZDHHC4-mediated palmitoylation. The pathway elements are clearly represented, with distinct color coding for different components and functions (e.g., positive and negative regulation). The layout of the diagram reflects the spatial organization specified in the description, with ZDHHC4 in the endoplasmic reticulum, AKT1 and GSK3B in the cytoplasm, and EZH2 on chromosomes. The use of arrows to indicate the direction and nature of regulation is clear and supports comprehension of the pathway dynamics. The different activities, such as palmitoyltransferase and protein serine/threonine kinase activities, are labeled alongside the relevant components, aiding understanding. The connection between components and their roles in cell migration regulation is visually distinguished, which enhances clarity. The addition of a comprehensive legend further aids interpretation of the diagram's elements.","necessary_changes":null,"optional_changes":null}