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Figure: Hippo signaling core components, WWC3 variant (Human).

id: gomodel:65bc474400000403

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This pathway diagram illustrates the Hippo signaling pathway with WWC3 variant in human cells. The diagram depicts:

  • Cytoplasmic signaling: WWC3 (signaling adaptor) and SAV1 (kinase activator) activate STK3/4 (serine/threonine kinases), which then phosphorylate and activate LATS1/2 kinases with assistance from MOB1A/B adaptor proteins.

  • Downstream regulation: Activated LATS1/2 phosphorylate YAP1 and WWTR1 (TAZ), marking them for cytoplasmic retention and inactivation.

  • Nuclear translocation: When the pathway is inactive, unphosphorylated YAP1 and WWTR1 translocate to the nucleus where they function as transcriptional coregulators.

  • Transcriptional control: In the nucleus, YAP1 and WWTR1 bind to TEAD transcription factors (shown as dashed elements as they are implied but not explicitly mentioned in the source data) to regulate gene expression.

Color coding distinguishes between adaptor proteins (pink), kinases (green), and transcriptional regulators (blue). Solid arrows represent direct interactions from the GO-CAM model, while dashed lines indicate translocation or implied interactions not explicitly in the source data.

Feedback from AI on figure:

{"feedback":"The diagram effectively illustrates the Hippo signaling pathway (WWC3 variant) in human cells with excellent clarity and scientific accuracy. The visual representation faithfully captures the content of the GO-CAM model while using appropriate artistic license to depict subcellular compartments and protein interactions. The color-coding system distinguishes between different protein types (adaptors, kinases, transcriptional regulators), making the pathway easy to interpret. All text is highly readable, and the functional descriptions for each protein enhance understanding of their roles in the pathway. The layout clearly shows the progression of signaling from cytoplasm to nucleus, and the arrows appropriately indicate the types of interactions (activation, phosphorylation, translocation). The legend effectively explains all visual elements, including the distinction between elements from the source data and implied components.","necessary_changes":null,"optional_changes":null}