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Figure: Role of CD53 in T-cell receptor signaling pathway (Human)

id: gomodel:65c57c3400002666

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This diagram illustrates the role of CD53 in T-cell receptor signaling pathway based on GO-CAM data. The pathway occurs at the plasma membrane of T cells and involves four key proteins:

  1. CD53 (Blue) - Functions as a membrane adaptor protein (GO:0043495) that initiates receptor clustering (GO:0043113)
  2. PTPRC (Orange) - A protein tyrosine phosphatase (GO:0004725) activated by CD53-mediated clustering
  3. LCK (Green) - A protein tyrosine kinase (GO:0004713) activated by PTPRC
  4. CD247 (Purple) - A transmembrane signaling receptor (GO:0004888) that is part of the T-cell receptor complex

The signaling cascade proceeds from left to right: CD53 mediates receptor clustering → PTPRC is activated → PTPRC activates LCK → LCK phosphorylates CD247 → T-cell receptor signaling (GO:0050852) occurs.

The diagram uses distinct shapes to represent different protein types (rounded rectangles for transmembrane proteins, specialized shapes for enzymes) and includes phosphorylation events (P circles) to show the mechanism of signal transduction.

Feedback from AI on figure:

{"feedback":"This scientific diagram effectively illustrates the role of CD53 in T-cell receptor signaling with professional clarity and precision suitable for publication in high-impact journals like Cell or Nature. The pathway components are clearly represented with appropriate protein shapes and consistent color coding that differentiates between protein types. The interaction arrows and phosphorylation events are accurately depicted, and the inclusion of GO terms adds scientific rigor. The cellular context (plasma membrane, extracellular/intracellular spaces) provides important spatial information for understanding the signaling pathway. The comprehensive legend will help readers interpret all aspects of the diagram.","necessary_changes":null,"optional_changes":"To further enhance this already excellent diagram, consider adding more cell biological context such as lipid rafts where these signaling events often occur, or indicating downstream signaling consequences beyond the immediate pathway shown. Also, depending on journal specifications, the GO identifiers could be moved to supplementary information to reduce visual clutter."}