Figure: DUSP22 inhibition of TCR signaling via UBR2 inhibition (Human)¶

This diagram illustrates the DUSP22 inhibition of TCR signaling via UBR2 inhibition pathway in human cells.

Key components: - DUSP22 (Q9NRW4): A dual-specificity phosphatase located at the plasma membrane - BTRC (Q9Y297): Beta-transducin repeat-containing protein in the cytoplasm - UBR2 (Q8IWV8): E3 ubiquitin-protein ligase in the cytoplasm - LCK (P06239): Lymphocyte-specific protein tyrosine kinase at the plasma membrane

The pathway shows how DUSP22 inhibits BTRC, which in turn inhibits UBR2, leading to UBR2 inhibition of LCK and ultimately negative regulation of T cell receptor signaling. The diagram illustrates molecular functions (phosphatase activity, ubiquitin ligase activities) and biological processes (TCR signaling, K48/K63-linked ubiquitination) involved in this regulatory pathway.

Feedback from AI on figure:

{"feedback":"The final diagram effectively illustrates the DUSP22 inhibition of TCR signaling pathway with excellent clarity and scientific accuracy. The visual representation clearly demarcates the cellular compartments (plasma membrane and cytoplasm) while accurately showing the inhibitory relationships between key proteins (DUSP22, BTRC, UBR2, and LCK). The following improvements have been incorporated successfully:\n\n1. Text legibility has been enhanced with larger font sizes for labels and descriptions\n2. Different interaction types are clearly differentiated using color-coded arrows and distinct markers\n3. Compartment labels are more prominent with increased font size and weight\n4. The legend is comprehensive and clearly explains the meaning of different arrow types\n\nThe diagram now maintains the scientific rigor expected in a high-quality journal figure while being visually accessible and easy to interpret.","necessary_changes":null,"optional_changes":null}