Figure: Thrombospondin-1/CD36 inhibition of angiogenesis in endothelial cells (Human)¶
The figure shows the molecular pathway of Thrombospondin-1/CD36 inhibition of angiogenesis in human endothelial cells. The pathway consists of four main steps: (1) Thrombospondin-1 (THBS1) in the extracellular matrix binds to CD36 receptor at the plasma membrane; (2) CD36 activates protein tyrosine phosphatase PTPN6 in the cytoplasm; (3) PTPN6 inhibits the vascular endothelial growth factor receptor KDR; (4) Inhibition of KDR prevents its normal function of promoting angiogenesis. This pathway represents a mechanism for negative regulation of angiogenesis (blood vessel formation).
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the Thrombospondin-1/CD36 inhibition pathway in endothelial cells with clear visual distinction between different cellular components. The sequential numbering system (steps 1-4) helps guide the viewer through the pathway, making the biological process more understandable. The color-coding consistently differentiates between proteins and their locations, while the varying line styles clearly show activation versus inhibition relationships. The added descriptive subtitle provides immediate context about the pathway's function.","necessary_changes":null,"optional_changes":null}