Figure: Activation of GPR75 by CCL5 in neurons (Human)¶
The figure illustrates the molecular pathway of GPR75 activation by CCL5 in human neurons. CCL5 (P13501) in the extracellular space exhibits chemokine activity that positively regulates GPR75 (O95800) on the plasma membrane. Upon activation, GPR75 initiates G protein-coupled receptor signaling that activates both MAPK3/ERK1 (P27361) and MAPK1/ERK2 (P28482) in the cytoplasm. These kinases participate in the ERK1 and ERK2 cascade (GO:0070371). Red arrows indicate chemokine activation, while blue arrows represent downstream signaling events. Numbered interaction points (1-3) mark key steps in the pathway.
Feedback from AI on figure:
{"feedback":"This scientific illustration effectively depicts the activation pathway of GPR75 by CCL5 in human neurons as described in the GO-CAM model. The drawing uses a clear visual hierarchy with appropriate cellular compartments (extracellular space, plasma membrane, and cytoplasm) and precise protein labeling including UniProt identifiers. The colored arrows distinguish between different types of signaling events, making the pathway directionality easy to follow. The subtle color gradient animations add visual interest while maintaining scientific rigor suitable for publication in journals like Cell or Nature. All components from the original GO-CAM are faithfully represented with their proper cellular locations and functional relationships.","necessary_changes":null,"optional_changes":"For even greater clarity in a print publication context, consider increasing the contrast of some text elements against their background and ensuring all font sizes remain readable when scaled down."}